The MBNL1 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to MBNL1. This antibody recognizes Human antigen. The MBNL1 Antibody has been validated for the following applications: ELISA, and Western Blot.
Description
Function: Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. Regulates the TNNT2 exon 5 skipping through competition with U2AF2. Inhibits the formation of the spliceosome A complex on intron 4 of TNNT2 pre-mRNA. Binds to the stem-loop structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Binds to the 5'-YGCU(U/G)Y-3'consensus sequence. Binds to the IR RNA. Binds to expanded CUG repeat RNA, which folds into a hairpin structure containing GC base pairs and bulged, unpaired U residues.
Subunit Structure: Interacts with DDX1 and YBX1. Interacts with HNRNPH1; the interaction in RNA-independent.
Similarity: Belongs to the muscleblind family